Document 0427
 DOCN  M9480427
 TI    Splenic rupture in hemophilia.
 DT    9410
 AU    Fort DW; Bernini JC; Johnson A; Cochran CJ; Buchanan GR; Department of
       Pediatrics, University of Texas Southwestern; Medical Center, Dallas.
 SO    Am J Pediatr Hematol Oncol. 1994 Aug;16(3):255-9. Unique Identifier :
       AIDSLINE MED/94311464
 AB    PURPOSE: Little information is available regarding splenic injury in
       patients with hemophilia. We describe here the management of splenic
       rupture in five of our patients with hemophilia and summarize the
       literature describing this complication. PATIENTS AND METHODS: Two human
       immunodeficiency virus-seropositive patients were managed medically and
       did not require splenectomy. A third patient had a high titer inhibitor
       to both porcine and human factor VIII and required emergency
       splenectomy. Two boys had not been previously diagnosed with hemophilia
       until they underwent splenectomy after abdominal trauma. RESULTS: All
       five patients survived. CONCLUSIONS: These cases demonstrate that
       nonsurgical management of splenic injury in patients with hemophilia can
       be performed safely and that splenectomy can be successfully performed
       despite a high titer of factor VIII inhibitor.
 DE    Adolescence  Case Report  Child  Child, Preschool
       Hemophilia/*COMPLICATIONS  Human  Male  Splenic
       Rupture/*ETIOLOGY/THERAPY  Support, Non-U.S. Gov't  Support, U.S. Gov't,
       P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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